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By Mayo Clinic staffAnaphylaxis isn't all that common, though many people are at risk of having an anaphylactic reaction. If you have a history of allergies or asthma, you may be at increased risk — especially if you've had a serious allergic reaction or an anaphylactic reaction before. Future reactions may be more severe than the first reaction, so if you've had a serious allergic reaction in the past, talk to your doctor.