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    Roger W. Harms, M.D.

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Question

Antibiotics and pregnancy: What's safe?

Is it safe to take antibiotics during pregnancy?

Answer

from Roger W. Harms, M.D.

If you develop a bacterial infection during pregnancy, antibiotics can nearly always be taken safely. The specific medication must be chosen carefully, however. Some antibiotics are OK to take during pregnancy, while others are not. Safety depends on various factors, including the type of antibiotic, when in your pregnancy you take the antibiotic, how much you take and for how long.

Here's a sampling of antibiotics generally considered safe during pregnancy:

  • Amoxicillin
  • Ampicillin
  • Clindamycin
  • Erythromycin
  • Penicillin

Certain other antibiotics should be avoided during pregnancy. For example, tetracyclines — such as doxycycline, tetracycline and minocycline — can damage a pregnant woman's liver, discolor a developing baby's teeth and cause various birth defects.

In addition, it's important to note that a recent study found an association between two classes of antibiotics commonly used to treat urinary tract infections — nitrofuran derivatives and sulfonamides — and rare birth defects. Although there's no direct proof that these antibiotics cause birth defects, additional research is needed. In the meantime, health care providers are likely to be more cautious in the use of these medications during pregnancy.

If an antibiotic is the best way to treat your condition — you have a urinary tract infection, for example, or you test positive for group B strep late in pregnancy (in which case antibiotics are given during labor) — your health care provider will prescribe the safest antibiotic at the safest dosage.

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References
  1. Briggs GG, et al. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins; 2008.
  2. Urinary tract infections. American College of Obstetricians and Gynecologists. http://www.acog.org/publications/patient_education/bp050.cfm. Accessed June 4, 2009.
  3. Group B streptococcus and pregnancy. American College of Obstetricians and Gynecologists. http://www.acog.org/publications/patient_education/bp105.cfm. Accessed June 4, 2009.
  4. Harms RW (expert opinion). Mayo Clinic, Rochester, Minn. Nov. 3, 2009.
  5. Crider KS, et al. Antibacterial medication use during pregnancy and risk of birth defects. Archives of Pediatrics & Adolescent Medicine. 2009;163:978.

AN01145

Nov. 6, 2009

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