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    Daniel K. Hall-Flavin, M.D.

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Question

Antidepressant withdrawal: Is there such a thing?

If you stop taking antidepressants, could you experience antidepressant withdrawal? Do withdrawal symptoms mean you were addicted to the drug?

Answer

from Daniel K. Hall-Flavin, M.D.

Antidepressant withdrawal is possible if you abruptly stop antidepressant therapy after taking the medication for an extended period — usually longer than six weeks. Signs and symptoms of antidepressant withdrawal are sometimes referred to as antidepressant discontinuation syndrome.

Signs and symptoms of antidepressant withdrawal may include:

  • Irritability
  • Anxiety
  • Sadness
  • Insomnia
  • Headaches
  • Dizziness
  • Fatigue
  • Nausea

To minimize the risk of antidepressant withdrawal, consult your doctor before you change the dosage or stop antidepressant therapy. Your doctor may recommend gradually tapering off the dosage for a number of weeks to allow your brain to adapt to the absence of the drug.

It's important to note that adjustment doesn't mean addiction. Antidepressants aren't considered addictive substances. Addiction represents harmful, long-term chemical changes in the brain. These changes can lead to tolerance, physical dependence and uncontrollable cravings. Withdrawal from an addictive substance is a very different phenomenon from withdrawal from antidepressants — which are simply drugs designed to restore normal chemical balance in the brain.

Keep in mind that it's sometimes difficult to differentiate between withdrawal symptoms and re-emergence of depression after you stop taking an antidepressant. Keep your doctor informed of your signs and symptoms. If necessary, your doctor may recommend resuming antidepressant therapy.

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AN01425

Sept. 11, 2008

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