Barrett's esophagus

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Causes

By Mayo Clinic staff

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Illustration showing Barrett's esophagus
Barrett's esophagus

The exact cause of Barrett's esophagus isn't known. Most people with Barrett's esophagus have long-standing GERD. It's thought that GERD causes stomach contents to wash back into the esophagus, causing damage to the esophagus. As the esophagus tries to heal itself, the cells can change to the type of cells found in Barrett's esophagus.

Still, some people diagnosed with Barrett's esophagus have never experienced heartburn or acid reflux. It's not clear what causes Barrett's esophagus in these cases.

References
  1. Rich HG. Barrett's esophagus. In: Ferri FF. Ferri's Clinical Advisor 2009: Instant Diagnosis and Treatment. Philadelphia, Pa.: Mosby Elsevier; 2009. http://www.mdconsult.com/das/book/body/145544773-3/0/1701/0.html. Accessed June 23, 2009.
  2. Wang KK, et al. Updated guidelines 2008 for the diagnosis, surveillance and therapy of Barrett's esophagus. American Journal of Gastroenterology. 2008;103:788.
  3. Azodo IA, et al. Barrett's esophagus. American College of Gastroenterology. http://www.acg.gi.org/patients/gihealth/barretts.asp. Accessed June 23, 2009.
  4. Shaheen NJ, et al. Barrett's oesophagus. The Lancet. 2009;373:850.
  5. Barrett's esophagus. National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddieases/pubs/barretts/index.htm. Accessed June 23, 2009.
  6. Crockett SD, et al. Health-related quality of life in patients with Barrett's esophagus: A systematic review. Clinical Gastroenterology and Hepatology. 2009;7:613.
  7. Waxman I, et al. Mucosal ablation of Barrett esophagus. Nature Reviews Gastroenterology & Hepatology. In press. http://www.nature.com/nrgastro/journal/vaop/ncurrent/abs/nrgastro.2009.90.html. Accessed June 24, 2009.
  8. Sharma P, et al. Management of nondysplastic Barrett's esophagus: Where are we now? American Journal of Gastroenterology. 2009;104:805.
  9. HALO 360 System. Barrx Medical, Inc. http://www.barrx.com/Patients_and_Families/index.cfm/421. Accessed June 25, 2009.
  10. Heartburn, gastroesophageal reflux (GER), and gastroesophageal reflux disease (GERD). National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/gerd/index.htm. Accessed June 29, 2009.

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Aug. 14, 2009

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