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By Mayo Clinic staffYou're likely to experience only the itchy skin welts that bedbugs cause while feeding. However, some people develop more complicated reactions to bedbug bites, such as clusters of inflamed red bumps, dilation of the capillaries under the skin, formation of pus-filled blisters and hives up to 8 inches across.
A rare possibility exists that anaphylactic shock may occur as an allergic reaction to the substances the bedbug injects while feeding.