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  • With Mayo Clinic obstetrician and medical editor-in-chief

    Roger W. Harms, M.D.

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Question

Blighted ovum: What causes it?

What causes a blighted ovum?

Answer

from Roger W. Harms, M.D.

A blighted ovum is a cause of early pregnancy loss. It occurs when a fertilized egg develops a placenta and membrane but no embryo — often due to chromosomal abnormalities in the fertilized egg. A blighted ovum usually occurs in the first few weeks of pregnancy, often before a woman even knows she's pregnant.

With a blighted ovum, a woman may miss a period and have a positive pregnancy test. This is because the placenta secretes human chorionic gonadotropin (HCG), a pregnancy hormone. Symptoms of early pregnancy — such as fatigue and breast tenderness — are possible as well. But when the placenta stops growing and hormone levels decrease, the pregnancy symptoms subside. At this point, minor abdominal cramping and light spotting or bleeding are possible. An ultrasound will show an empty gestational sac.

A blighted ovum eventually results in miscarriage. Some women choose to wait for the miscarriage to happen naturally, while others take medication to trigger the miscarriage. In some cases, a procedure called dilation and curettage (D and C) is used to remove the placental tissues.

Most women who've had a blighted ovum go on to have successful pregnancies. If you experience multiple consecutive miscarriages, you might consider testing to identify any underlying causes.

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References
  1. Cleary-Goldman J, et al. Multiple gestations. In: Gabbe SG, et al. Obstetrics: Normal and Problem Pregnancies. 5th ed. Churchill Livingstone/Elsevier; 2007. http://www.mdconsult.com/das/book/body/103262410-3/740962730/1528/296.html#4-u1.0-B978-0-443-06930-7..50030-X--cesec21_1369. Accessed Aug. 28, 2008.
  2. Uzelac P, et al. Early pregnancy risks. In: DeCherney AH, et al. Current Diagnosis & Treatment Obstetrics & Gynecology. 10th ed. The McGraw-Hill Companies; 2007. http://www.accessmedicine.com/content.aspx?aID=2384827&searchStr=blighted+ovum. Accessed Aug. 28, 2008.
  3. Abortion. In: Cunningham FG, et al. Williams Obstetrics. 22nd ed. The McGraw-Hill Companies; 2005. http://www.accessmedicine.com/content.aspx?aID=742710&searchStr=blighted+ovum. Accessed Aug. 28, 2008.

AN00418

Nov. 26, 2008

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