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Breast cancer prevention: Lifestyle factors that can reduce risk

Birth control pills and breast cancer prevention: No easy answers

There's no evidence of an across-the-board link between birth control pill use and breast cancer risk. Analysis of combined data from many older studies suggests a slight increase in risk of premenopausal breast cancer. The pills used in these studies, however, include preparations that contained higher estrogen doses than what is available in preparations prescribed today. The analysis of these older oral contraceptives also showed that women who took the pill for four or more years before their first full-term pregnancy had a larger increase in premenopausal breast cancer risk. Still, experts analyzing all the risk data estimate that birth control pill use causes, at most, 4.7 out of 10,000 cases of premenopausal breast cancer.

Pesticides and antibiotics: Use with caution

Breast cancer incidence may be linked to both pesticide exposure and overuse of antibiotics. But research isn't conclusive. Until further studies are conducted and more is known about these possible links, be aware of how these substances might counterbalance your efforts at breast cancer prevention.

  • Exposure to pesticides. The molecular structure of some pesticides closely resembles that of estrogen. This means they may attach to estrogen receptor sites in your body. Although studies haven't found a definite link between most pesticides and breast cancer, researchers have learned that women with elevated levels of pesticides in their breast tissue have a greater breast cancer risk.
  • Unnecessary antibiotics. Scientists recently found a link between antibiotic use and breast cancer — the longer antibiotics were used, the greater the risk of breast cancer. Researchers caution, however, that other factors, such as underlying illness or a weakened immune system, rather than antibiotics themselves, may account for the elevated cancer risk.

Do what you can

In addition to lifestyle changes, be vigilant about early detection of breast cancer. If you notice any breast changes, such as a new lump or skin changes, make an appointment to see your doctor for evaluation. Ask your doctor when you should begin mammograms and other screening procedures to detect breast cancer.

Nothing you do can guarantee your life will be cancer-free. But if you practice healthy habits and consult your doctor about extra measures you can take, you may at least reduce your risk of this potentially fatal disease.

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References
  1. Kushi LH, et al. American Cancer Society guidelines on nutrition and physical activity for cancer prevention: Reducing the risk of cancer with healthy food choices and physical activity. CA: A Cancer Journal for Clinicians. 2006;56:254.
  2. Stein C, et al. Cancer prevention. http://www.uptodate.com/home/index.html. Accessed Nov. 14, 2008.
  3. Zhang SM, et al. Alcohol consumption and breast cancer risk in the Women's Health Study. American Journal of Epidemiology. 2007;165:667.
  4. McTiernan A. Behavioral risk factor in breast cancer: Can risk be modified? The Oncologist. 2003;8:326.
  5. Prentice RL, et al. Low-fat dietary pattern and risk of invasive breast cancer: The Women's Health Initiative randomized controlled dietary modification trial. The Journal of the American Medical Association. 2006;295:629.
  6. Chlebowski RT, et al. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women. The Journal of the American Medical Association. 2003;289:3243.
  7. Brinton LA, et al. Menopausal hormone therapy and breast cancer risk in the NIH-AARP diet and health study cohort. Cancer Epidemiology, Biomarkers & Prevention. 2008;17:3150.
  8. Questions and answers about the WHI postmenopausal hormone therapy trials. National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/whi/whi_faq.htm. Accessed Nov. 18, 2008.
  9. Kahlenborn C, et al. Oral contraceptive use as a risk factor for premenopausal breast cancer: A meta-analysis. Mayo Clinic Proceedings. 2006;81:1290.
  10. Cerhan JR. Oral contraceptive use and breast cancer risk: Current status. Mayo Clinic Proceedings. 2006;81:1287.
  11. Velicer CM, et al. Antibiotic use in relation to the risk of breast cancer. JAMA: The Journal of the American Medical Association. 2004;291:827.
  12. Brody JG, et al. Environmental pollutants and breast cancer. Cancer. 2007;109(suppl):2667.

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Nov. 18, 2009

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