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Get StartedSide effects of hormone therapy for breast cancer
By Mayo Clinic staffHere's a look at the known side effects of tamoxifen and aromatase inhibitors:
Tamoxifen
- Mimics the signs and symptoms of menopause, including hot flashes, irregular periods and vaginal discharge
- Causes a slight but definite increase in your risk of cancers of the uterus (endometrial cancer or uterine sarcoma) and your risk of cataracts
- Places premenopausal women at higher risk of developing osteoporosis
- Slightly increases risk of blood clots and stroke
Aromatase inhibitors
- Can cause hot flashes, but not to the degree that tamoxifen does
- Slightly increase your risk of joint pain
- Slightly increase your risk of muscle aches
- May slightly increase your risk of osteoporosis and bone fractures