Broken heart syndrome

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Causes

By Mayo Clinic staff

It's thought that a brief surge of stress hormones, such as adrenaline, might temporarily damage the hearts of some people. How these hormones might hurt the heart or whether something else is responsible isn't clear.

Broken heart syndrome is often preceded by an intense physical or emotional event. Some of the triggers of broken heart syndrome have included news of an unexpected death of a loved one, a frightening medical diagnosis, domestic abuse or losing a lot of money. Physical stressors, such as an asthma attack, a car accident or major surgery, also have been known to trigger broken heart syndrome.

How is broken heart syndrome different from a heart attack?
Most heart attacks are caused by a complete blockage of a heart artery due to a blood clot forming at the site of narrowing from fatty buildup (atherosclerosis). In broken heart syndrome, the heart arteries are not blocked, although blood flow in the arteries of the heart may be reduced.

References
  1. Reeder GS. Stress-induced (takotsubo) cardiomyopathy. http://www.uptodate.com/index. Accessed Jan. 12, 2009.
  2. Wittstein IS, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. New England Journal of Medicine. 2005;352:539.
  3. Wittstein IS. The broken heart syndrome. Cleveland Clinic Journal of Medicine. 2007;7:S17.
  4. Gianni M, et al. Apical ballooning syndrome or takotsubo cardiomyopathy: A systematic review. European Heart Journal. 2006;27:1523.
  5. Merli E, et al. Tako-Tsubo cardiomyopathy: New insights into the possible underlying pathophysiology. European Journal of Echocardiography. 2006;7:53.
  6. Prasad A (expert opinion). Mayo Clinic. Rochester, Minn. Jan. 19, 2009.

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Feb. 12, 2009

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