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By Mayo Clinic staffChronic exertional compartment syndrome isn't a life-threatening condition and usually doesn't cause any lasting or permanent damage if you seek appropriate treatment. However, if you continue to exercise despite pain, the repeated increases in compartment pressure can lead to muscle, nerve and blood vessel damage. As a result, you may develop permanent numbness or weakness in affected muscles.
Perhaps the biggest complication of untreated chronic exertional compartment syndrome is its impact on participation in your favorite sports — the pain may prevent you from being active.