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Complications
By Mayo Clinic staffClaudication can be worsened by some medications, such as beta blockers. They can reduce blood flow or cause your blood vessels to constrict, interfering with circulation. If you're taking beta blockers, make sure you talk to your doctor about decreasing the dose or stopping this medication. Your claudication may also worsen in colder temperatures.
In extreme cases, the circulation in your legs can be so limited that you feel pain even when you aren't exercising, and your legs might feel cool to the touch. Though rare, severe cases can lead to poor healing of skin injuries and ulcers. These cuts and ulcers can develop gangrene and require amputation.
