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  • With Mayo Clinic psychiatrist

    Daniel K. Hall-Flavin, M.D.

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Mayo Clinic Health Manager

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Question

'Clinical depression': What does that mean?

What does the term "clinical depression" mean?

Answer

from Daniel K. Hall-Flavin, M.D.

Depression ranges in seriousness from mild, temporary episodes of sadness to severe, persistent depression. Doctors use the term "clinical depression" to describe the more severe, persistent form of depression also known as "major depression" or "major depressive disorder." Signs and symptoms of clinical depression may include:

  • Loss of interest in daily activities
  • Persistent sadness or feeling of emptiness
  • Sleep disturbances
  • Significant weight loss or gain
  • Loss of concentration
  • Fatigue
  • Suicidal thoughts or behavior

For most forms of depression, symptoms improve with psychological counseling, antidepressant medications or a combination of the two. Antidepressants can relieve symptoms of depression, while counseling may help you cope with ongoing problems that may trigger or contribute to depression.

If you have severe depression, or counseling and medications don't relieve your symptoms, you may benefit from electroconvulsive therapy (ECT) — a procedure in which electric currents are passed through the brain.

Other, newer treatments also show promise for difficult-to-treat depression. These include vagus nerve stimulation (VNS) and deep brain stimulation (DBS). These treatments both affect the mood center of the brain with electrical currents that pass through surgically implanted electrodes. Another new treatment, called transcranial magnetic stimulation (TMS), was recently approved by the FDA. It uses strong magnets to stimulate the parts of the brain that affect mood.

Next question
Depression and anxiety: Can I have both?
References
  1. Major depressive disorder. In: Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR. 4th ed. Arlington, Va.: American Psychiatric Association; 2000. http://www.psychiatryonline.com. Accessed March 9, 2009.
  2. Major depression. National Alliance on Mental Illness. http://www.nami.org/PrinterTemplate.cfm?Template=/ContentManagement/HTMLDisplay.cfm&ContentID=39059. Accessed March 9, 2009.

AN01057

April 23, 2009

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