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Complications

By Mayo Clinic staff

Dementia can affect the functioning of many body systems and, therefore, the ability to carry out day-to-day tasks. Dementia may lead to problems such as:

  • Inadequate nutrition. Nearly everyone who has dementia will at some point reduce or stop eating and drinking. Often, advanced dementia causes people to lose control of the muscles used to chew and swallow, putting them at risk of choking or aspirating food into their lungs. If this happens, it can block breathing and cause pneumonia. People with advanced dementia also lose the feeling of hunger and, with it, the desire to eat. Depression, side effects of medications, constipation, and other conditions such as infections also can decrease a person's interest in food.
  • Reduced hygiene. In the moderate to severe stages of dementia, you lose the ability to independently complete daily living tasks. You may no longer be able to bathe, dress, brush your teeth and go to the toilet on your own.
  • Difficulty taking medications. Because a person's memory is affected, remembering to take the correct amount of medications at the right time can be challenging.
  • Deterioration of emotional health. Dementia changes behaviors and personality. Some of the changes may be caused by the actual deterioration happening in a person's brain, while other behavioral and personality changes may be reactions to the emotional challenges of coping with the deterioration changes. Dementia may lead to depression, aggression, confusion, frustration, anxiety, a lack of inhibition and disorientation.
  • Difficulty communicating. As dementia progresses, the ability to remember the names of people and things may be lost. This makes communication difficult at all levels, whether to let a caregiver know what you need and how you feel or simply to communicate socially. Difficulty communicating can lead to feelings of agitation, isolation and depression.
  • Delirium. This state is characterized by a decline in attention, awareness and mental clarity. Delirium is common in people with dementia, especially when admitted to the hospital. It appears that the sudden change in surroundings, activity level and other routines may be the cause.
  • Problems sleeping. Disruption of the normal sleep-wake cycle — being up at night and sleeping during the day — is very common. Insomnia is another common complication, as are restless legs syndrome and sleep apnea, which can also interfere with sleep.
  • Personal safety challenges. Because of a reduced capacity for decision making and problem solving, some day-to-day situations can present safety issues for people with dementia. These include driving, cooking, falling and negotiating obstacles.
References
  1. Chertkow H. Diagnosis and treatment of dementia: Introduction. Canadian Medical Association Journal. 2008;178:316.
  2. Feldman HH, et al. Diagnosis and treatment of dementia: 2. Dementia. Canadian Medical Association Journal. 2008;178:825.
  3. Dementia: Hope through research. National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/disorders/dementias/detail_dementia.htm#1318919213. Accessed Jan. 3, 2009.
  4. National Institute on Aging. Frontotemporal dementia: Growing interest in a rare dementia. http://www.nia.nih.gov/Alzheimers/Publications/FTDreprint.htm. Accessed Jan. 11, 2009.
  5. Ersek M, et al. Tube feeding decisions for people with advanced dementia. The AGS Foundation for Health in Aging. http://www.healthinaging.org/public_education/pef/tube_feeding.php. Accessed Jan. 24, 2009.
  6. Dementia Guidelines for Early Detection, Diagnosis and Management of Dementia. New York, N.Y.: The American Geriatrics Society. http://www.americangeriatrics.org/products/positionpapers/aan_dementiaPF.shtml. Accessed Jan. 24, 2009.
  7. Farlow M. Moderate to severe Alzheimer disease — definition and clinical relevance. Neurology. 2005;65(suppl):S1.
  8. Hsiung G-YR, et al. Genetics and dementia: Risk factors, diagnosis, and management. Alzheimer's & Dementia. 2007;3:418.
  9. Patterson C, et al. General risk factors for dementia: A systematic evidence review. Alzheimer's & Dementia. 2007;3:341.
  10. Fuhrer R, et al. Exploring sex differences in the relationship between depressive symptoms and dementia incidence: Prospective results from the PAQUID study. Journal of the American Geriatric Society. 2003;51:1055.
  11. Wang H-X, et al. Late-life engagement in social and leisure activities is associated with a decreased risk of dementia: A longitudinal study from the Kungsholmen project. American Journal of Epidemiology. 2002:155:1081.
  12. Barberger-Gateau P. Diet and risk of dementia or cognitive decline. Alzheimers & Dementia. 2008;4(suppl):T181.
  13. Xu W-L, et al. Mid- and late-life diabetes in relation to the risk of dementia: A population-based twin study. Alzheimers & Dementia. 2008;4(suppl):T119.
  14. Biessels GJ, et al. Risk of dementia in diabetes mellitus: A systemic review. The Lancet Neurology. 2006;5:64.
  15. Kramer A, et al. Inflammation and Alzheimer's disease: Possible role of periodontal disease. Alzheimer's & Dementia. 2008;4;242.
  16. Tyas SL, et al. Risk factors for Alzheimer's disease: A population-based, longitudinal study in Manitoba, Canada. International Journal of Epidemiology. 2001;30:590.
  17. Hogan DB, et al. Diagnosis and treatment of dementia: 4. Approach to management of mild to moderate dementia. Canadian Medical Association Journal. 2008;179:787.
  18. Hogan DB, et al. Diagnosis and treatment of dementia: 5. Nonpharmacologic and pharmacologic therapy for mild to moderate dementia. Canadian Medical Association Journal. 2008;179:1019.
  19. Dementia. Alzheimer's Association. http://www.alz.org/alzheimers_disease_dementia.asp. Accessed Feb. 8, 2009.
  20. Steps to diagnosis. Alzheimer's Association. http://www.alz.org/alzheimers_disease_steps_to_diagnosis.asp#physexam. Accessed Feb. 9, 2009.
  21. Haan MN, et al. Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: Results from the Sacramento area Latino study on aging. The American Journal of Clinical Nutrition. 2007;85:511. http://www.ajcn.org/cgi/reprint/85/2/511. Accessed Feb. 9, 2009.
  22. Alternative treatments. Alzheimer's Association. http://www.alz.org/alzheimers_disease_alternative_treatments.asp#Coenzyme_Q10. Accessed Feb. 9, 2009.

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April 17, 2009

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