Mayo Clinic Health Manager
Get free personalized health guidance for you and your family.
Get StartedDepression (major depression)
In-Depth
Definition
- Mental health: What's normal, what's not Mental health vs. mental illness — Find out how mental illnesses are diagnosed and defined.
Risk factors
- Depression in women: Understanding the gender gap Depression in women — Learn what factors may set the stage for their increased risk.
- Stress symptoms: Effects on your body, feelings and behavior Stress symptoms — Learn how stress can affect your health so you can take action.
Symptoms
- Male depression: Understanding the issues Male depression — Understand symptoms, consequences and coping skills.
- Depression self-assessment Take this depression self-assessment to help learn whether you have symptoms of depression.
- Symptom Checker Use this Symptom Checker to pinpoint possible causes of your medical symptoms.
Tests and diagnosis
- Mental health providers: Find one to suit your needs Mental health providers: Find the best one for you
- Cytochrome P450 (CYP450) genotyping test CYP450 test — Overview covers definition, test results analyzing how your body processes certain antidepressants.
Treatments and drugs
- Serotonin syndrome Serotonin syndrome — Comprehensive overview covers symptoms, treatment of condition caused by too much medication.
- Antidepressants: Are they safe during pregnancy? Antidepressants are central to treating depression. But during pregnancy, it's important to weigh risks.
- Transcranial magnetic stimulation Transcranial magnetic stimulation — Overview covers definition, risks, results of this procedure to treat depression.
- Family therapy Family therapy — Overview covers definition, benefits and what to expect from family-centered therapy.
- Cognitive behavioral therapy Cognitive behavioral therapy — Overview covers definition, risks, results of this procedure to treat mental illness.
- Psychotherapy Psychotherapy — Overview covers definition, risks, results of this procedure to treat mental illness.
- Vagus nerve stimulation Vagus nerve stimulation — Overview covers definition, risks, results of this procedure to treat depression
- Deep brain stimulation Deep brain stimulation — Overview covers definition, risks, results of this procedure to treat depression.
- Antidepressants: Selecting one that's right for you Antidepressants — Explore options to treat depression.
- Treatment-resistant depression: Explore options when depression doesn't get better Treatment-resistant depression — Find out what you can do about depression that doesn't get better.
- Monoamine oxidase inhibitors (MAOIs) MAOIs: The first and still-popular class of antidepressants — how they work and side effects.
- Selective serotonin reuptake inhibitors (SSRIs) SSRIs — Discover how SSRI antidepressants relieve depression, and what side effects they may cause.
- Serotonin and norepinephrine reuptake inhibitors (SNRIs) Antidepressant SNRIs — Here's how this dual reuptake inhibitor works and its possible side effects.
- Norepinephrine and dopamine reuptake inhibitors (NDRIs) Antidepressant NDRIs — What to know about this dual reuptake inhibitor and its side effects.
- Tetracyclic antidepressants Tetracyclics — Find out how this antidepressant type helps mental health and about side effects.
- Tricyclic antidepressants (TCAs) Tricyclics — Discover how this class of antidepressants works and their possible side effects.
- Combined reuptake inhibitors and receptor blockers Combined inhibitors and blockers — Here's how these dual-action antidepressants work and possible side effects.
- Transcranial magnetic stimulation Transcranial magnetic stimulation — Overview covers definition, risks, results of this procedure to treat depression.
- Deep brain stimulation Deep brain stimulation — Overview covers definition, risks, results of this procedure to treat depression.
- Electroconvulsive therapy (ECT) Electroconvulsive therapy (ECT) — Overview covers definition, risks, results of this treatment for depression.
- Antidepressants: Get tips to cope with side effects Antidepressants — Side effects are common, but don't give up without trying these coping tips.
Lifestyle and home remedies
- Depression and anxiety: Exercise eases symptoms Depression symptoms often improve with exercise. Here are tips to help you get started.
- Meditation: Take a stress-reduction break wherever you are Meditation — Learn quick and easy ways to meditate, no matter where you are.
- Seasonal affective disorder treatment: Choosing a light therapy box Seasonal affective disorder treatment — Get tips for choosing a light therapy box.
Alternative medicine
- Treatment-resistant depression: Explore options when depression doesn't get better Treatment-resistant depression — Find out what you can do about depression that doesn't get better.
Coping and support
- Support groups: Share experiences about depression, mental health conditions Support groups for depression or other mental health conditions offer coping help.
- Depression: Supporting a family member or friend with depression Depression — How to help a family member or friend dealing with this debilitating illness.
- Mental health: Overcoming the stigma of mental illness Mental health — Understand and overcome the stigma of mental illness and mental health disorders.
- Support groups: Find information, encouragement and camaraderie Find information on types of support groups, and how to choose the right one.