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Before Using
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of fluticasone and salmeterol combination in children older than 4 years of age. Safety and efficacy have not been established for children younger than 4 years old.
Appropriate studies have not been performed on the relationship of age to the effects of Advair® HFA oral inhalation in children younger than 12 years of age. Safety and efficacy have not been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fluticasone and salmeterol combination in the elderly. However, elderly people with heart and blood vessel problems may require special caution when receiving fluticasone and salmeterol combination.
Pregnancy
| Pregnancy Category | Explanation | |
|---|---|---|
| All Trimesters | C | Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. |
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acebutolol
- Alprenolol
- Arotinolol
- Atazanavir
- Atenolol
- Befunolol
- Betaxolol
- Bevantolol
- Bisoprolol
- Bopindolol
- Brofaromine
- Bucindolol
- Bupranolol
- Bupropion
- Carteolol
- Carvedilol
- Celiprolol
- Clarithromycin
- Clorgyline
- Darunavir
- Dilevalol
- Esmolol
- Furazolidone
- Indinavir
- Iproniazid
- Isocarboxazid
- Itraconazole
- Ketoconazole
- Labetalol
- Landiolol
- Lazabemide
- Levobetaxolol
- Levobunolol
- Linezolid
- Mepindolol
- Metipranolol
- Metoprolol
- Moclobemide
- Nadolol
- Nebivolol
- Nefazodone
- Nelfinavir
- Nialamide
- Nipradilol
- Oxprenolol
- Pargyline
- Penbutolol
- Phenelzine
- Pindolol
- Procarbazine
- Propranolol
- Rasagiline
- Ritonavir
- Saquinavir
- Selegiline
- Sotalol
- Talinolol
- Telithromycin
- Tertatolol
- Timolol
- Tipranavir
- Toloxatone
- Tranylcypromine
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Erythromycin
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Asthma attack, acute or
- Bronchospasm (difficulty with breathing), acute or
- COPD flare-up or
- Milk protein allergy, severe—Should not be used in patients with these conditions.
- Blood vessel disease (e.g., Churg-Strauss syndrome) or
- Bone problems (e.g., osteoporosis) or
- Cataracts or
- Glaucoma or
- Heart disease or
- Heart rhythm problems (e.g., arrhythmia) or
- Hypertension (high blood pressure) or
- Hyperthyroidism (overactive thyroid) or
- Hypokalemia (low potassium in the blood) or
- Seizures, history of—Use with caution. May make these conditions worse.
- Chickenpox (including recent exposure) or
- Herpes simplex (virus) infection of the eye or
- Infections (virus, bacteria, or fungus) or
- Measles or
- Tuberculosis, active or history of—Inhaled fluticasone can reduce the body's ability to fight off these infections.
- Diabetes mellitus or
- Ketoacidosis (high ketones in the blood)—Blood sugar levels may increase.
- Infection or
- Stress or
- Surgery or
- Trauma—Supplementary oral corticosteroids may be needed. Check with your doctor.
- Liver disease—Use with caution. Effects may be increased because of slower removal of the medicine from the body.
