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Definition
By Mayo Clinic staffFibrous dysplasia is a bone disorder in which scar-like (fibrous) tissue develops in place of normal bone. As the bone grows, the softer, fibrous tissue expands, weakening the bone. Fibrous dysplasia can cause the affected bone to deform and become susceptible to fracture.
Mild cases of fibrous dysplasia usually cause no signs or symptoms. More-serious cases may result in bone pain and deformity, which usually develop before age 15.
The basic cause of fibrous dysplasia is unknown. There's no cure for fibrous dysplasia. Treatment focuses on relieving signs and symptoms.
- Fibrous dysplasia. American Academy of Orthopaedic Surgeons. http://orthoinfo.aaos.org/topic.cfm?topic=A00083. Accessed May 11, 2009.
- DiCaprio MR, et al. Fibrous dysplasia. Pathophysiology, evaluation, and treatment. The Journal of Bone & Joint Surgery. 2005;87:1848.
- Leet AI, et al. Current approach to fibrous dysplasia of bone and McCune-Albright syndrome. Journal of Children's Orthopaedics. 2007;1:3.
- Polyostotic fibrous dysplasia. Craniofacial & Skeletal Diseases Branch, Division of Intramural Research, National Institute of Dental and Craniofacial Research. http://csdb.nidr.nih.gov/frame_clinical_bkg.htm. Accessed May 11, 2009.
- Glorieux FH, et al. Medical therapy of children with fibrous dysplasia. Journal of Bone and Mineral Research. 2006;21(suppl):P110.
- Chapurlat RD, et al. Fibrous dysplasia of bone and McCune-Albright syndrome. Best Practice & Research Clinical Rheumatology. 2008;22:55.
