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Definition
By Mayo Clinic staffGangrene refers to the decay and death of tissue resulting from an interruption of blood flow to a certain area of your body. Some types of gangrene also involve a bacterial infection. Gangrene most commonly affects the extremities, including your toes, fingers and limbs, but it can also occur in your muscles and internal organs.
Your chances of developing gangrene are higher if you have an underlying condition that can damage your blood vessels and impede blood flow, such as diabetes or atherosclerosis.
Treatments for gangrene include surgery to remove dead tissue, antibiotics and other approaches. The prognosis for recovery is good if gangrene is identified early and treated quickly.
- Meislin HW, et al. Soft tissue infections. In: Marx JA, et al., eds. Rosen's Emergency Medicine: Concepts and Clinical Practice. 6th ed. St. Louis, Mo.: Mosby; 2006. http://www.mdconsult.com/das/book/body/141947879-3/849444931/1365/420.html#4-u1.0-B0-323-02845-4..50140-2_7293. Accessed June 4, 2009.
- Stevens DL. Necrotizing fasciitis, gas gangrene, myositis and myonecrosis. In: Cohen J, et al. Infectious Diseases. 2nd ed. St. Louis, Mo.: Mosby; 2004. http://www.mdconsult.com/das/book/body/141947879-5/849445124/1209/32.html#4-u1.0-B0-323-02407-6..50012-X_334. Accessed June 4, 2009.
- Stevens DL. Necrotizing infections of the skin and fascia. http://www.uptodate.com/home/index.html. Accessed June 4, 2009.
- Abrahamian FM, et al. Management of skin and soft-tissue infections in the emergency department. Infectious Disease Clinics of North America. 2008;22:89.
- May AK. Skin and soft tissue infections. Surgical Clinics of North America. 2009;89:403.
- Kaide CG. Hyperbaric oxygen: Applications in infectious disease. Emergency Medicine Clinics of North America. 2008;26:571.
- Neschis DG. Clinical manifestations and evaluation of chronic critical limb ischemia. http://www.uptodate.com/home/index.html. Accessed June 4, 2009.
- Sepsis and septic shock. The Merck Manuals: The Merck Manual for Healthcare Professionals. http://www.merck.com/mmpe/sec06/ch068/ch068a.html. Accessed June 4, 2009.
- Anderson DJ, et al. Skin and soft tissue infections in older adults. Clinics in Geriatric Medicine. 2007;23:595.
- Sheps SG (expert opinion). Mayo Clinic, Rochester, Minn. June 6, 2009.
