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Causes
By Mayo Clinic staff
GERD is caused by frequent acid reflux — the backup of stomach acid or bile into the esophagus.
When you swallow, the lower esophageal sphincter — a circular band of muscle around the bottom part of your esophagus — relaxes to allow food and liquid to flow down into your stomach. Then it closes again.
However, if this valve relaxes abnormally or weakens, stomach acid can flow back up into your esophagus, causing frequent heartburn and disrupting your daily life. This constant backwash of acid can irritate the lining of your esophagus, causing it to become inflamed (esophagitis). Over time, the inflammation can erode the esophagus, causing complications such as bleeding or breathing problems.
- Heartburn, gastroesophageal reflux (GER), and gastroesophageal reflux disease (GERD). National Institute of Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/gerd/index.htm. Accessed April 17, 2009.
- Kahrilas PJ, et al. American Gastroenterological Association Institute Technical Review on the Management of Gastroesophageal Reflux Disease. Gastroenterology. 2008;135:1392.
- Heartburn. American Gastroenterological Society. http://www.gastro.org/wmspage.cfm?parm1=848. Accessed April 17, 2009.
- Richter JE. Gastroesophageal reflux disease and its complications. In: Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2006. http://www.mdconsult.com/das/book/body/133141408-5/0/1389/0.html. Accessed April 17, 2009.
- Liu JJ, et al. Endoscopic treatment of gastroesophageal reflux disease. American College of Gastroenterology. http://www.acg.gi.org/patients/gihealth/grdtrtmnt.asp. Accessed April 17, 2009.
- Kahrilas PJ, et al. American Gastroenterological Association medical position statement on the management of gastroesophageal reflux disease. Gastroenterology. 2008;135:1383.
- Kiefer D. Gastroesophageal reflux disease. In: Rakel D. Integrative Medicine. 2nd ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/133141408-4/0/1494/0.html. Accessed April 22, 2009.
- Dickman R, et al. Clinical trial: Acupuncture vs. doubling the proton pump inhibitor in refractory heartburn. Alimentary Pharmacology & Therapeutics. 2007;26:1333.
