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    Timothy Moynihan, M.D.

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Question

Ginger for chemotherapy-induced nausea: Does it work?

Can taking ginger for nausea reduce or eliminate nausea and vomiting caused by chemotherapy?

Answer

from Timothy Moynihan, M.D.

The evidence is mixed on whether taking ginger for nausea is effective in reducing or eliminating nausea and vomiting during and after chemotherapy. On the one hand, there have been promising results from some studies of ginger for nausea, including one that showed taking various doses of ginger orally had a significant effect in reducing nausea in people undergoing chemotherapy for a variety of cancers. In two other smaller studies, taking ginger along with a standard anti-nausea (anti-emetic) medication further reduced the severity of nausea following chemotherapy treatments. And in another small study, people receiving ginger combined with a high-protein drink reported less nausea than those who did not receive the ginger and protein drink.

But other studies have shown ginger to be of no benefit in reducing nausea and vomiting due to chemotherapy. It also had been thought that taking ginger might reduce the length of time people feel nauseous following chemotherapy, but no solid evidence has been found to support that, either.

Additional study is needed. In the meantime, several prescription drugs have been proven effective at controlling nausea during and after chemotherapy. Discuss with your health care team what might be best for you.

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References
  1. Ryan JL, et al. Ginger for chemotherapy-related nausea in cancer patients: A URCC CCOP randomized, double-blind, placebo-controlled clinical trial of 644 cancer patients. Journal of Clinical Oncology. 2009;15(suppl):9511.
  2. Hickok JT, et al. A phase II/III randomized, placebo-controlled, double-blind clinical trial of ginger (zingiber officinale) for nausea caused by chemotherapy for cancer: A currently accruing URCC CCOP cancer control study. Supportive Cancer Therapy. 2007;4:247.
  3. Zick SM, et al. Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting. Support Care Cancer. 2009;17:563.
  4. Ginger. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed Aug. 11, 2009.
  5. Levine ME, et al. Protein and ginger for the treatment of chemotherapy-induced delayed nausea. The Journal of Alternative and Complementary Medicine. 2008;14:545.

AN02018

Aug. 21, 2009

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