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  • With Mayo Clinic clinical neuropsychologist

    Glenn Smith, Ph.D.

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Mayo Clinic Health Manager

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Question

Ginkgo biloba: Can it prevent memory loss?

Can ginkgo biloba prevent memory loss and improve cognitive function in people with Alzheimer's disease?

Answer

from Glenn Smith, Ph.D.

Ginkgo biloba, derived from the leaves of the Ginkgo biloba tree, is often touted as a memory aid, but it's still unclear whether ginkgo biloba can prevent memory loss associated with mild cognitive impairment or Alzheimer's disease.

Small, early studies have shown modest improvements in cognitive function for older adults with dementia. However, a large-scale study, published in a November 2008 issue of the Journal of the American Medical Association, found no evidence that ginkgo biloba prevents memory loss or slows the progression of dementia among those who had mild cognitive impairment at the start of the study.

More studies are needed to determine possible benefits and long-term risks of ginkgo biloba. For now, ginkgo biloba is generally recognized as safe if taken as directed and under the guidance of your doctor. However, bleeding may be a concern when ginkgo biloba is taken with other medications because it may affect the clotting process. Don't use ginkgo biloba if you're taking anti-clotting medications, such as warfarin (Coumadin) or aspirin, or medications that can affect bleeding, such as ibuprofen (Advil, Motrin, others). Consult with your doctor before starting any dietary supplement.

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References
  1. DeKosky ST, et al. Ginkgo biloba for prevention of dementia: A randomized controlled trial. Journal of the American Medical Association. 2008;300:2253.
  2. Ginkgo. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed Feb. 18, 2009.
  3. Saper R. Clinical use of ginkgo biloba. http://www.uptodate.com/home/index.html. Accessed March 3, 2009.
  4. Kelly BJ, et al. Alternative medicine and Alzheimer disease. Neurologist. 2008;14:299.
  5. Birks J, et al. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database of Systematic Reviews. 2007:CD003120.

AN01981

May 22, 2009

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