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Human growth hormone (HGH): Does it slow aging?
Human growth hormone is described by some as the key to slowing the aging process. Before you sign up, get the facts — and understand proven ways to promote healthy aging.
By Mayo Clinic staffGrowth hormone is produced by the pituitary gland — a pea-sized structure at the base of the brain — to fuel childhood growth and help maintain tissues and organs throughout life. Beginning in middle age, however, the pituitary gland slowly reduces the amount of growth hormone it produces. This natural slowdown has prompted an interest in the use of synthetic human growth hormone (HGH) to stave off the realities of old age. However, there's little evidence to suggest human growth hormone can help otherwise healthy adults regain youth and vitality.
Who needs to take human growth hormone?
Synthetic human growth hormone, which must be injected, is available only by prescription. It's approved to treat adults who have true growth hormone deficiency — not the expected decline in growth hormone due to aging.
Studies of adults who have a growth hormone deficiency show that injections of human growth hormone can:
- Increase bone density
- Increase muscle mass
- Decrease body fat
- Increase exercise capacity
Human growth hormone is also approved to treat AIDS- or HIV-related muscle wasting.
What can human growth hormone do for otherwise healthy adults?
Studies of healthy adults taking human growth hormone are limited. Although it appears that human growth hormone injections can increase muscle mass and reduce the amount of body fat in healthy older adults, the increase in muscle doesn't translate into increased strength. In fact, researchers have found that strength training is a cheaper, more effective way to increase muscle mass and strength.
It isn't clear if human growth hormone may provide other benefits to healthy adults.
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- Smit P, et al. Growth hormone therapy and risk of malignancy. The Endocrinologist. 2008;18:39.
- Nass R, et al. Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults. Annals of Internal Medicine. 2008;149:601.
- Liu H, et al. Systemic review: The safety and efficacy of growth hormone in the healthy elderly. Annals of Internal Medicine. 2007;146:104.
- Giannoulis MG, et al. The effects of growth hormone and/or testosterone on whole body protein kinetics and skeletal muscle gene expression in healthy elderly men: A randomized controlled trial. Journal of Clinical Endocrinology & Metabolism. 2008;93:3066.
- Blackman MR. Use of growth hormone secretagogues to prevent or treat the effects of aging: Not yet ready for prime time. Annals of Internal Medicine. 2008;149:677.
- Olshansky SJ, et al. New developments in the illegal provision of growth hormone for 'anti-aging' and bodybuilding. Journal of the American Medical Association. 2008;299:2792.
- Can we prevent aging? National Institute on Aging. http://www.nia.nih.gov/HealthInformation/Publications/preventaging.htm. Accessed Dec. 11, 2008.
- Import alert no. 66-71: Detention without physical examination of human growth hormone (HGH), also known as somatropin. U.S. Food and Drug Administration. http://www.fda.gov/ora/fiars/ora_import_ia6671.html. Accessed Dec. 11, 2008.
