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By Mayo Clinic staffThis condition is more common in infants with a family history of hypospadias.
There also may be an increased risk of hypospadias in infant males born to women of an advanced age or those who used in vitro fertilization (IVF) to conceive. The connection to IVF may be due to the mother's exposure to progesterone, a natural hormone, or to progestin, a synthetic form of progesterone, administered during the IVF process.
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- Conte FA, et al. Disorders of sexual determination & differentiation. In: Gardner DG, et al. Greenspan's Basic & Clinical Endocrinology. 8th ed. USA: The McGraw-Hill Companies; 2007. www.accessmedicine.com/popup.aspx?aID=2633104&print=yes. Accessed Oct. 14, 2008.