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Causes
By Mayo Clinic staffDoctors believe that juvenile rheumatoid arthritis is an autoimmune disorder. This means that the body's immune system attacks its own cells and tissues. It's unknown why this happens, but both heredity and environment seem to play a role. Certain gene mutations may make a person more susceptible to environmental factors — such as viruses — that may trigger the disease.
- Questions and answers about juvenile arthritis. National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/Health_Info/Juv_Arthritis/default.asp. Accessed Aug. 27, 2009.
- Miller ML, et al. Juvenile rheumatoid arthritis. In: Kliegman RM, et al. Nelson Textbook of Pediatrics. 18th ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/das/book/body/157224368-3/881801128/1608/462.html#4-u1.0-B978-1-4160-2450-7..50156-0_3615. Accessed Aug. 31, 2009.
- Arthritis in children. American College of Rheumatology. http://www.rheumatology.org/public/factsheets/diseases_and_conditions/juvenilearthritis.asp. Accessed Sept. 1, 2009.
- Grom AA, et al. Immunopathogenesis of juvenile rheumatoid arthritis. http://www.uptodate.com/home/index.html. Accessed Aug. 31, 2009.
- Juvenile rheumatoid arthritis: How is it diagnosed? Arthritis Foundation. http://www.arthritis.org/disease-center.php?disease_id=38&df=diagnosed. Accessed Aug. 31, 2009.
- Lehman TJ. Management of polyarticular onset juvenile rheumatoid arthritis. http://www.uptodate.com/home/index.html. Accessed Sept. 1, 2009.
- Juvenile arthritis. American Academy of Orthopaedic Surgeons. http://orthoinfo.aaos.org/topic.cfm?topic=A00075. Accessed Sept. 1, 2009.
- Juvenile rheumatoid arthritis: Treatment options. Arthritis Foundation. http://www.arthritis.org/disease-center.php?disease_id=38&df=treatments. Accessed Sept. 1, 2009.
- JA Alliance. Arthritis Foundation. http://www.arthritis.org/ja-alliance-main.php. Accessed Sept. 1, 2009.
