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Treatments and drugs

By Mayo Clinic staff

Treatment can be challenging, and there's no cure for Lewy body dementia. Instead, doctors treat the individual symptoms.

Medications

  • Cholinesterase inhibitors. These Alzheimer's disease medications work by increasing the levels of neurotransmitters — chemical messengers believed to be important for memory, thought and judgment — in the brain. This can help improve alertness and cognition, and may help reduce hallucinations and other behavioral problems.
  • Parkinson's disease medications. These medications can help reduce Parkinson's-like muscular symptoms in some people with Lewy body dementia, but they can also cause increased confusion, hallucinations and delusions.
  • Antipsychotic medications. These medications may somewhat improve delusions and hallucinations. However, at least a third of the people who have Lewy body dementia have a dangerous sensitivity to some of these types of drugs. Reactions, which are sometimes irreversible, can include severe Parkinson's-like symptoms and a worsening of confusion.

Therapies
Because antipsychotic drugs can worsen the symptoms of Lewy body dementia, it might be better to initially try nondrug approaches, such as:

  • Modify the environment. Reducing clutter and distracting noise can make it easier for someone with dementia to focus and function.
  • Modify the response. A caregiver's response to a behavior can make the behavior worse. It's best to avoid correcting and quizzing a person with dementia. Reassuring the person and validating his or her concerns can defuse most situations.
  • Modify tasks. Break tasks into easier steps and focus on success, not failure. Structure and routine also help people with dementia feel safe.

DS00795

Sept. 17, 2008

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