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    Daniel K. Hall-Flavin, M.D.

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Question

MAOIs and diet: Is it necessary to restrict tyramine?

I just started taking MAOIs for depression. Do I really need to follow a low-tyramine diet?

Answer

from Daniel K. Hall-Flavin, M.D.

A low-tyramine diet is important for anyone who's taking monoamine oxidase inhibitors (MAOIs).

Tyramine is a naturally occurring amino acid that helps regulate blood pressure. Tyramine is present in various foods, such as certain cheeses, wines and meats. Tyramine can also result from the bacterial breakdown of protein in foods as they age. Also, the amount of tyramine can vary among specific brands of certain foods due to different processing, storage and preparation methods.

In turn, MAOIs impair the function of the enzyme monoamine oxidase — which is responsible for the breakdown of tyramine in the body. If you include too much tyramine in your diet while you're taking MAOIs, you may experience a dangerous increase in blood pressure. Eventually, excess tyramine in your blood could trigger a stroke.

While you're taking MAOIs, your doctor may recommend eating only fresh foods — not leftovers or foods past their freshness dates. Other tyramine-rich foods and beverages to avoid may include:

  • Avocados
  • Bananas
  • Broad bean (fava bean) pods
  • Chocolate
  • Aged cheese and any dish prepared with aged cheese
  • Sausage, pepperoni and salami
  • Sauerkraut
  • Soy sauce
  • Tap beer
  • Red wine, including Chianti

If you haven't received one already, ask your doctor or a registered dietitian for a complete list of foods to avoid while you're taking MAOIs.

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