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Dosing
The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.
Adults (18 years and older)
Studies have evaluated 0.5-50 milligrams of melatonin taken nightly by mouth. Research suggests that quick-release melatonin may be more effective than sustained-release formulations for sleep related conditions. Intramuscular injections of 20 milligrams of melatonin have also been studied.
In studies of patients with melanoma, melatonin preparations have been applied to the skin. Patients are advised to discuss cancer treatment plans with an oncologist and pharmacist before considering use of melatonin either alone or with other therapies.
Intranasal melatonin (1% solution in ethanol) at a dose of 2 milligrams daily for one week has also been studied for high blood pressure.
There are other uses with limited study and unclear effectiveness or safety. Use of melatonin for any condition should be discussed with a primary healthcare provider, appropriate specialist and pharmacist prior to starting and should not be substituted for more proven therapies.
Children (younger than 18 years)
There is limited study of melatonin supplements in children, and safety is not established. Use of melatonin should be discussed with the child's physician and pharmacist prior to starting.
NS_patient-melatonin
Portions of this document last updated:Sept. 1, 2009
THE NATURAL STANDARD RESEARCH COLLABORATION
(www.naturalstandard.com)
