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Ergots for migraine treatment
By Mayo Clinic staffErgotamine has been around for decades. It was a common prescription choice for migraines before triptans were introduced. It's available in tablet and suppository form.
Ergotamine is less expensive than are triptans, but it may not work as efficiently. Ergotamine is poorly absorbed when it's taken orally or rectally. Dihydroergotamine, an ergot derivative, is more effective and has fewer side effects than ergotamine. It's available as an injection or nasal spray.
Nausea and vomiting, common side effects of ergotamine, occur less often with dihydroergotamine. Other side effects of both drugs include dizziness, tingling or prickling sensations, abdominal cramps, chest tightness, flushing, restlessness and anxiety.
Don't take these medicines if you're pregnant, breast-feeding or have:
- Uncontrolled high blood pressure
- Hyperthyroidism
- Kidney or liver disease
