Mild cognitive impairment

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Causes

By Mayo Clinic staff

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MRI of brain shrinkage Brain shrinkage

Mild cognitive impairment often causes the same types of brain changes seen in Alzheimer's disease or other forms of dementia. The difference is in the extent of these changes, which is limited in mild cognitive impairment. These changes may include:

  • Plaques, which are abnormal clumps of a protein called beta-amyloid
  • Tangles, which are abnormal clumps of a protein called tau
  • Shrinkage of the hippocampus, an area of the brain important for memory
  • Strokes
  • Lewy bodies, which are abnormal clumps of a protein that's associated with Parkinson's disease

DS00553

Aug. 26, 2008

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