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By Mayo Clinic staffYou may choose to make a skin examination a regular part of your preventive medical care. Talk to your doctor about a schedule that's appropriate for you. Your doctor will examine your skin from head to toe, including your scalp, your palms, the soles of your feet and the skin between your buttocks. If your doctor suspects that a mole may be cancerous, he or she may take a sample of the tissue (biopsy) and submit the biopsy for microscopic examination.