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By Mayo Clinic staffPeripheral artery disease can lead to open sores that don't heal, injury, or infection of your feet and legs, especially if you also have diabetes. Critical limb ischemia (CLI) is the extreme state of this condition and can cause tissue death (gangrene), sometimes requiring amputation of the affected limb.
Stroke and heart attack are among the more serious and common complications of peripheral artery disease. Atherosclerosis causing signs and symptoms of peripheral artery disease is not limited to your legs. Fat deposits also build up in arteries supplying your heart and brain. As a result, you have a greater risk of coronary artery disease and stroke.