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    Timothy Moynihan, M.D.

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Question

Photodynamic therapy: An effective treatment for lung cancer?

Is photodynamic therapy an effective treatment for lung cancer?

Answer

from Timothy Moynihan, M.D.

Photodynamic therapy may play a limited role in lung cancer treatment — generally complementing, rather than replacing, other forms of treatment.

Photodynamic therapy begins with the injection of a light-sensitive medication into a specific vein. One to three days later, the doctor shines light of a certain wavelength onto the tumor from inside the body — typically using a thin, lighted tube called a bronchoscope, which can be passed through the mouth into the lungs. The light destroys the cells that have absorbed the medication, as well as other cells in the area. The goal is to shrink or control the tumor, which can help relieve symptoms such as bleeding, shortness of breath and wheezing.

After photodynamic therapy, the affected area is highly sensitive to light. Generally, it's best to avoid any exposure to bright light, including the sun, for up to six weeks after treatment.

Photodynamic therapy isn't effective for widespread cancers or tumors that can't be reached by the light.

Next question
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References
  1. Moynihan TJ (expert opinion). Mayo Clinic, Rochester, Minn. Sept. 21, 2008.
  2. Ernst A, et al. Photodynamic therapy of lung cancer. http://www.uptodate.com/home/index.html. Accessed Sept. 22, 2008.
  3. Photodynamic therapy for cancer: Questions and answers. National Cancer Institute. http://www.cancer.gov/cancertopics/factsheet/Therapy/photodynamic. Accessed Sept. 22, 2008.
  4. Zuluaga MF, et al. Combination of photodynamic therapy with anti-cancer agents. Current Medicinal Chemistry. 2008;15(17):1655-1673.

AN01932

Oct. 18, 2008

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