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Complications
By Mayo Clinic staffComplications of pulmonary fibrosis may include:
- Low blood-oxygen levels (hypoxemia). Because pulmonary fibrosis reduces the amount of oxygen you take in and the amount that enters your bloodstream, you're likely to develop lower than normal blood-oxygen levels. Lack of oxygen can disrupt your body's basic functioning, and severely low levels can be life-threatening.
- High blood pressure in your lungs (pulmonary hypertension). Unlike systemic high blood pressure, this condition affects only the arteries in your lungs. It begins when the smallest arteries and capillaries are compressed by scar tissue, causing increased resistance to blood flow in your lungs. This in turn raises pressure within the pulmonary arteries. Pulmonary hypertension is a serious illness that becomes progressively worse and may eventually prove fatal.
- Right-sided heart failure (cor pulmonale). This serious condition occurs when your heart's lower right chamber (ventricle) has to pump harder than usual to move blood through blocked pulmonary arteries.
- Respiratory failure. This is often the last stage of chronic lung disease. It occurs when blood-oxygen levels fall dangerously low. Low blood-oxygen levels can lead to heart arrhythmias and unconsciousness.
References
- Garantziotis S, et al. Serum inter-alpha-trypsin inhibitor and matrix hyaluronan promote angiogenesis in fibrotic lung injury. American Journal of Respiratory and Critical Care Medicine. 2008;178:939.
- Interstitial lung disease and pulmonary fibrosis. American Lung Association. http://www.lungusa.org/site/apps/nlnet/content3.aspx?c=dvLUK9O0E&b=4294229&ct=3052333. Accessed Jan. 13, 2008.
- King TE. Clinical advances in the diagnosis and therapy of the interstitial lung diseases. American Journal of Respiratory and Critical Care Medicine. 2005;172:26.
- What are the signs and symptoms of idiopathic pulmonary fibrosis? National Heart Lung and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/ipf/ipf_signsandsymptoms.html. Accessed Jan. 13, 2009.
- How is idiopathic pulmonary fibrosis treated? National Heart Lung and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/ipf/ipf_treatments.html, Accessed Jan, 13, 2009.
- McKay S, et al. Patient information handbook. Chicago, Ill.: American Pulmonary Fibrosis Foundation; 2004. http://www.pulmonaryfibrosis.org/patient.pdf. Accessed Jan 13, 2009.
- What causes idiopathic pulmonary fibrosis? National Heart Lung and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/ipf/ipf_causes.html. Accessed Jan. 14, 2009.
- Idiopathic pulmonary fibrosis: Diagnosis and treatment: International consensus statement. American Journal of Respiratory and Critical Care Medicine. 2000;161:646.
