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Treatments and drugs

By Mayo Clinic staff

Once an underlying condition is effectively treated, secondary hypertension may decrease or even return to normal. Often, however, lifestyle changes — such as eating healthy foods, increasing physical activity and maintaining a healthy weight — can help keep your blood pressure low.

You may need to continue to take blood pressure medication as well, such as:

  • Thiazide diuretics. Diuretics, sometimes called water pills, are medications that act on your kidneys to help your body eliminate sodium and water, reducing blood volume. Thiazide diuretics are often the first — but not the only — choice in high blood pressure medications. If you're not taking a diuretic and your blood pressure remains high, talk to your doctor about adding one or replacing a drug you currently take with a diuretic.
  • Beta blockers. These medications reduce the workload on your heart and open your blood vessels, causing your heart to beat slower and with less force. When prescribed alone, beta blockers don't work as well in blacks — but they're effective when combined with a thiazide diuretic.
  • Angiotensin-converting enzyme (ACE) inhibitors. These medications help relax blood vessels by blocking the formation of a natural chemical that narrows blood vessels. ACE inhibitors may be especially important in treating high blood pressure in people with coronary artery disease, heart failure or kidney failure. Like beta blockers, ACE inhibitors don't work as well in blacks when prescribed alone, but they're effective when combined with a thiazide diuretic.
  • Angiotensin II receptor blockers. These medications help relax blood vessels by blocking the action — not the formation — of a natural chemical that narrows blood vessels. Like ACE inhibitors, angiotensin II receptor blockers often are useful for people with coronary artery disease, heart failure and kidney failure.
  • Calcium channel blockers. These medications help relax the muscles of your blood vessels. Some slow your heart rate. Calcium channel blockers may work better for blacks than do ACE inhibitors or beta blockers alone. A word of caution for grapefruit lovers, though. Grapefruit juice interacts with some calcium channel blockers, increasing blood levels of the medication and putting you at higher risk of side effects. Talk to your doctor or pharmacist if you're concerned about interactions.

Treatment can sometimes be complicated. But once you know you have high blood pressure, you can work with your doctor to control it.

References
  1. Chobanian AV, et al. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003;42(6)1202-1256.
  2. Onusko E. Diagnosing secondary hypertension. American Family Physician. 2003;68(1):67-74.
  3. Taler SJ. Secondary causes of hypertension. Primary Care: Clinics in Office Practice. 2008;35(3):489-500.
  4. Domino FJ, et al. Overview of hypertension in adults. http://www.uptodate.com. Accessed Sept. 18, 2008.
  5. Ong KL, et al. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension. 2007;49(1):69-75.
  6. Polycystic kidney disease. National Institute of Diabetes and Digestive and Kidney Diseases. http://kidney.niddk.nih.gov/kudiseases/pubs/polycystic/. Accessed Sept. 16, 2008.
  7. Glomerulonephritis. National Kidney Foundation. http://www.kidney.org/atoz/atozPrint.cfm?id=65 Accessed Sept. 16, 2008.
  8. Bilateral hydronephrosis. University of Maryland Medical Center. http://www.umm.edu/ency/article/000474all.htm. Accessed Sept. 16, 2008.
  9. ATA hypothyroidism booklet. American Thyroid Association. http://www.thyroid.org/patients/brochures/Hypothyroidism%20_web_booklet.pdf. Accessed Sept. 16, 2008.
  10. Hyperthyroidism. American Thyroid Association. http://www.thyroid.org/patients/brochures/Hyper_brochure.pdf. Accessed Sept. 16, 2008.
  11. Hyperparathyroidism. National Institute of Diabetes and Digestive and Kidney Diseases. http://endocrine.niddk.nih.gov/pubs/hyper/hyper.htm. Accessed Sept. 16, 2008.
  12. What is preeclampsia? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/hbp/issues/preg/preclamp.htm. Accessed Sept. 16, 2008.

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Oct. 4, 2008

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