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    Timothy Moynihan, M.D.

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Question

Small cell lung cancer: Can brain radiation prevent spread?

My husband has small cell lung cancer and his doctors have suggested preventive radiation therapy to his brain. What is the benefit of brain radiation?

Answer

from Timothy Moynihan, M.D.

Preventive brain radiation reduces the risk that cancer will spread to the brain in people with small cell lung cancer. Unfortunately, even in people who have a complete remission of small cell lung cancer, there is a high risk that the cancer will eventually spread to the brain.

Preventive brain radiation can reduce the risk of neurological problems caused by cancer. But people who receive preventive brain radiation don't live substantially longer than people who wait until cancer has spread to the brain before trying brain radiation.

Brain radiation is not without its risks. Long-term side effects may include memory loss, confusion and difficulty concentrating.

Your husband and his cancer doctor (oncologist) must weigh the potential risks and benefits of preventive brain radiation in your husband's specific situation. For some people, radiation is worthwhile to prevent disease from spreading to the brain. Others may want to avoid the side effects of preventive brain radiation and take a wait-and-see approach to the need for such treatment.

Next question
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References
  1. Simon GR, et al. Management of small cell lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 2007;132(suppl):324S.
  2. Castrucci WA, et al. An update on the treatment of CNS metastases in small cell lung cancer. The Cancer Journal. 2008;14:138.
  3. Moynihan TJ (expert opinion). Mayo Clinic, Rochester, Minn. July 8, 2009.

AN01675

Aug. 27, 2009

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