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Risk factors

By Mayo Clinic staff

There aren't many known risk factors for type 1 diabetes, though researchers continue to find new possibilities. Some known risk factors include:

  • A family history. Anyone with a parent or siblings with type 1 diabetes has a slightly increased risk of developing the condition.
  • Genetics. The presence of certain genes indicates an increased risk of developing type 1 diabetes. In some cases — usually through a clinical trial — genetic testing can be done to determine if a child who has a family history of type 1 diabetes is at increased risk of developing the condition.

Possible risk factors for type 1 diabetes include:

  • Viral exposure. Exposure to Epstein-Barr virus, coxsackievirus, mumps or cytomegalovirus may trigger the autoimmune destruction of the islet cells, or the virus may directly infect the islet cells.
  • Low vitamin D levels. Research suggests that vitamin D may protect against type 1 diabetes. However, early intake of cow's milk — a common source of vitamin D — has been linked to an increased risk of type 1 diabetes.
  • Other dietary factors. Omega-3 fatty acids may offer some protection against type 1 diabetes, while drinking water that contains nitrates may increase the risk. Additionally, the timing of the introduction of cereal into a baby's diet may affect his or her risk of type 1 diabetes. One clinical trial found that between ages 3 and 7 months appears to be the optimal time for introducing cereal.

Some other possible risk factors include a young maternal age (less than 25), a mother with preeclampsia during pregnancy, and a baby with jaundice or a respiratory infection occurring just after birth.

Complications Causes
References
  1. The dangerous toll of diabetes. American Diabetes Association. http://www.diabetes.org/diabetes-statistics/dangerous-toll.jsp. Accessed Jan. 6, 2009.
  2. Levitsky LL, et al. Epidemiology, presentation, and diagnosis of type 1 diabetes mellitus in children and adolescents. http://www.uptodate.com/home.index.html. Accessed Jan. 5, 2009.
  3. Eisenbarth GS, et al. Pathogenesis of type 1 diabetes mellitus. http://www.uptodate.com/home.index.html. Accessed Jan. 5, 2009.
  4. McCulloch DK. Glycemic control and vascular complications in type 1 diabetes mellitus. http://www.uptodate.com/home.index.html. Accessed Jan. 5, 2009.
  5. Kidney disease (nephropathy). American Diabetes Association. http://www.diabetes.org/utils/printthispage.jsp?PageID=TYPE1DIABETES3_232930. Accessed Jan. 6, 2009.
  6. What is diabetes: Diabetes complications. Juvenile Diabetes Research Foundation. http://www.jdrf.org/index.cfm?page_id=101308. Accessed Jan. 6, 2009.
  7. Prevent diabetes problems: Keep your eyes healthy. National Institute of Diabetes and Digestive and Kidney Diseases. http://diabetes.niddk.nih.gov/dm/pubs/complications_eyes/index.htm. Accessed Jan. 6, 2009.
  8. McCulloch DK. Patient information: Preventing complications in diabetes mellitus. http://www.uptodate.com/home.index.html. Accessed Jan. 5, 2009.
  9. Skin complications. American Diabetes Association. http://www.diabetes.org/utils/printthispage.jsp?PageID=TYPE1DIABETES3_232934. Accessed Jan. 6, 2009.
  10. What people with diabetes need to know about osteoporosis. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Accessed Jan. 9, 2009.
  11. Levitsky LL, et al. Management of type 1 diabetes mellitus in children and adolescents. http://www.uptodate.com/home.index.html. Accessed Jan. 5, 2009.
  12. Standards of medical care in diabetes -2009. Alexandria, Va.: American Diabetes Association. http://care.diabetesjournals.org/content/vol31/Supplement_1/. Accessed Jan. 28, 2009.
  13. Estimated average glucose, eAG. American Diabetes Association. http://professional.diabetes.org/GlucoseCalculator.aspx. Accessed Jan. 6, 2009.
  14. The basics of insulin. American Diabetes Association. http://www.diabetes.org/utils/printthispage.jsp?PageID=TYPE1DIABETES3_263601. Accessed Jan. 6, 2009.
  15. McCulloch DK. Patient information: Insulin therapy in type 1 diabetes mellitus. http://www.uptodate.com/home.index.html. Accessed Jan. 5, 2009.
  16. Levitsky LL, et al. Complications and screening in children and adolescents with type 1 diabetes mellitus. http://www.uptodate.com/home.index.html. Accessed Jan. 5, 2009.
  17. Robertson RP. Pancreas and islet transplantation in diabetes mellitus. http://www.uptodate.com/home.index.html. Accessed Jan. 6, 2009.
  18. Low blood sugar: Definition, symptoms. Juvenile Diabetes Research Foundation. http://www.jdrf.org/index.cfm?fuseaction=home.viewpage&page_id=EC9AC822-1321-C844-13C1013CF597E42F. Accessed Jan. 6, 2009.
  19. High blood sugar: Definition, symptoms. Juvenile Diabetes Research Foundation. http://www.jdrf.org/index.cfm?fuseaction=home.viewpage&page_id=EC92D98E-1321-C844-13EB771367A49526. Accessed Jan. 6, 2009.
  20. Ketoacidosis. American Diabetes Association. http://www.diabetes.org/type-1-diabetes/ketoacidosis.jsp. Accessed Jan. 6, 2009.
  21. Collazzo-Clavell M (expert opinion). Mayo Clinic, Rochester, Minn. Jan. 21, 2009.
  22. Diabetes and teens. Juvenile Diabetes Research Foundation. Accessed Jan. 20, 2009.
  23. Stalvey MS. Fifty years ago in the Journal of Pediatrics. Journal of Pediatrics. 2007: 150(1) http://www.mdconsult.com/das/article/body/115791309-2/jorg=journal&source=&sp=16726925&sid=788957128/N/562819/1.html?issn=0022-3476. Accessed Jan. 6, 2009.
  24. What is Type 1 Diabetes TrialNet? Type 1 Diabetes TrialNet. http://www.diabetestrialnet.org/about/index.htm. Accessed Jan. 6, 2009.
  25. International Expert Committee. International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes. Diabetes Care. 2009;32:1.

DS00931

June 13, 2009

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