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Causes
By Mayo Clinic staff
Heart defects that are present at birth (congenital) arise from errors early in the heart's development, but there's often no clear cause. Genetics and environmental factors probably play a role.
A ventricular septal defect occurs when the septum, the muscular wall separating the heart into left and right sides, fails to form fully between the lower chambers of the heart (ventricles) during fetal development. This leaves an opening that allows mixing of new ("red," or oxygenated) blood and used ("blue," or deoxygenated) blood.
As a result, blood overfills the lungs and overworks the heart. If the defect is severe and not treated, the blood pressure in the lungs goes up (pulmonary hypertension) and the ventricles enlarge and no longer work efficiently. Ultimately, this can lead to irreversible damage to the lung arteries and to heart failure.
- What are holes in the heart? National Heart, Lung, and Blood Institute. http://www.nhlbi.nih.gov/health/dci/Diseases/holes/holes_whatare.html. Accessed Aug. 4, 2009.
- Ventricular septal defect (VSD). American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=11066. Accessed Aug. 4, 2009.
- Webb GD, et al. Congenital heart disease. In: Libby P, et al., eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2007. http://www.mdconsult.com/book/player/book.do?method=display&type=bookPage&decorator=header&eid=4-u1.0-B978-1-4160-4106-1..50064-9--cesec134&displayedEid=4-u1.0-B978-1-4160-4106-1..50064-9--cesec166&uniq=152762796&isbn=978-1-4160-4106-1#lpState=open&lpTab=contentsTab&content=4-u1.0-B978-1-4160-4106-1..50064-9%3Bfrom%3Dtoc%3Btype%3DbookPage%3Bisbn%3D978-1-4160-4106-1. Accessed Aug. 4, 2009.
- Dummer KB, et al. Pathophysiology and clinical features of isolated ventricular septal defects in infants and children. http://www.uptodate.com/home/index.html. Accessed Aug. 4, 2009.
- McMackin,CJ, et al. Ventricular septal defect. In: Ferri FF. Ferri's Clinical Advisor 2009. St. Louis, Mo.: Mosby; 2008. http://www.mdconsult.com/das/book/body/152762796-4/871305879/1701/628.html#4-u1.0-B978-0-323-04134-8..50025-2--subchapter8_13432. Accessed Aug. 4, 2009.
- Congenital heart defects. American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=4565. Accessed Aug. 4, 2009.
- Dummer KB, et al. Management of isolated ventricular septal defects in infants and children. http://www.uptodate.com/home/index.html. Accessed Aug. 4, 2009.
- Prevention of infective endocarditis: Guidelines from the American Heart Association. Circulation. 2007;116:1736.
- Genetic counseling for adults with congenital heart disease. American Heart Association. http://www.americanheart.org/presenter.jhtml?identifier=11083. Accessed Aug. 20, 2009.
