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continued:

Weight-loss drugs: Can a prescription help you lose weight?

Effectiveness: Modest but can improve health

Combining weight-loss drugs with a low-calorie diet and regular exercise can help you lose more weight than can either drugs or lifestyle changes alone. Combining all three — medication, fewer calories and more activity — can help you lose anywhere from 5 percent to 10 percent of your total body weight within a year.

This may not seem like many pounds lost, but even modest weight loss has a significant benefit to your health. Losing just a small percentage of your weight can decrease:

  • Blood pressure
  • Blood triglyceride levels
  • Blood glucose levels
  • Insulin levels

Weight-loss drugs don't replace the need for changes in your eating habits or activity level. They mainly improve your chances of achieving clinically significant weight loss — the amount of weight loss that has a positive impact on your health.

Drug safety: Still largely unknown

If you're among those who can benefit from a weight-loss drug, you'll likely need to take it indefinitely. When you stop drug treatment, however, much or all of the lost weight generally returns. The dilemma with taking the drugs indefinitely is that the most common weight-loss drugs are so new that possible long-term effects are unknown.

Sibutramine can cause a small increase in blood pressure that, for some people, may warrant discontinuing the drug. This drug isn't recommended for people with uncontrolled high blood pressure, heart disease, irregular heartbeat or a history of stroke.

Orlistat decreases the absorption of certain fat-soluble vitamins — for example, vitamins A, D and E. If you're taking this drug, your doctor will recommend that you take a daily vitamin supplement to prevent potential nutrient deficiencies.

Factors to consider

You and your doctor need to carefully evaluate the potential benefits of taking a drug and weigh them against the possible long-term risks. Your doctor will also consider your health history, the possible side effects and the potential interaction of weight-loss drugs with other medications you're taking.

Keep in mind that some health insurance plans don't cover weight-loss prescription drugs. And some companies may require prior authorization before covering the expense. If you're unsure of your prescription coverage, contact your health insurance provider.

These medications can help you with weight maintenance, especially if you continue exercising regularly. But keeping off the pounds once you've lost them is an ongoing concern. And despite your efforts, you might still regain the weight.

As you consider weight-loss drugs, make sure that you make every effort to exercise, change your eating habits and adjust any other lifestyle factors that have contributed to your excess weight. Weight-loss drugs aren't the easy answer to weight loss, but they can be a useful tool to help you make the necessary diet and lifestyle changes.

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Feb. 15, 2008

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