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Symptoms
By Mayo Clinic staffWilson's disease causes a wide variety of signs and symptoms that are often mistaken for other diseases and conditions. Signs and symptoms vary depending on what parts of your body are affected by Wilson's disease.
Signs and symptoms of Wilson's disease include:
- Clumsiness
- Depression
- Difficulty speaking
- Difficulty swallowing
- Difficulty walking
- Drooling
- Easy bruising
- Fatigue
- Involuntary shaking
- Joint pain
- Loss of appetite
- Nausea
- Skin rash
- Swelling of arms and legs
- Yellowing of the skin and eyes (jaundice)
When to see a doctor
Make an appointment with your doctor if you have any signs and symptoms that worry you.
If a family member has been diagnosed with Wilson's disease, tell your doctor at your next appointment. Your doctor may recommend tests to determine whether you may have Wilson's disease.
- Cox DW, et al. Wilson disease. In: Feldman M, et al. Sleisenger & Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management. 8th ed. Philadelphia, Pa.: Saunders Elsevier; 2006. http://www.mdconsult.com/das/book/body/153549812-5/0/1389/0.html. Accessed Aug. 11, 2009.
- Roberts EA, et al. Diagnosis and treatment of Wilson disease: An update. Hepatology. 2008;47:2089.
- Wilson disease. National Institute for Diabetes and Digestive and Kidney Diseases. http://digestive.niddk.nih.gov/ddiseases/pubs/wilson. Accessed Aug. 11, 2009.
- ATP7B. Genetics Home Reference. http://ghr.nlm.nih.gov/gene=atp7b. Accessed Aug. 11, 2009.
- Copper, Cu (mg) content of selected foods. USDA National Nutrient Database for Standard Reference, Release 21. http://www.nal.usda.gov/fnic/foodcomp/Data/SR21/nutrlist/sr21w312.pdf. Accessed Aug. 18, 2009.
- Picco MF (expert opinion). Mayo Clinic, Jacksonville, Fla. Sept. 14, 2009.
